Do I have to leave the desktop wallet running to stake Radix?

No, there’s no need to leave your wallet open for staking to happen!
Radix uses a DPoS (Delegated Proof of Stake) system to reach consensus, which is different compared to a PoW (Proof of Work) system like Bitcoin.
Your stake is being handled by the validator node you delegated it to.

You can obviously also turn off your computer.

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